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Youakim SALIBA

Youakim SALIBA

professeur associé

Faculté de médecine – Coordinateur des enseignements Laboratoire de physiologie et physiopathologie

+961 (1) 421 000 ext 6828 youakim.saliba@usj.edu.lb

Dr. Youakim Saliba is an academic and researcher in the field of health sciences. He is currently engaged as an Associate Professor at the Faculty of Medicine of the Saint Joseph University of Beirut, where he has been serving since 2012. Dr. Saliba also holds an academic editor position at the journal Cardiovascular Therapeutics since 2022.Dr. Saliba's educational background is extensive. He earned his PhD in 2012 from Sorbonne Université, specializing in Physiology and Pathophysiology with a thesis on the identification of STIM1 partners in normal and hypertrophied hearts. He completed his Master's in Research in Biology - Health, specializing in Physiology, from USJ in 2008, and prior to that, a Bachelor's degree in Biological Sciences from the Lebanese University in 2007.His research focuses on cardiovascular physiology and pathophysiology, contributing significantly to the understanding of cardiac and renal fibrosis mechanisms. Dr. Saliba is a prolific author, having published numerous articles in high-impact journals, and actively participates in international scientific conferences, presenting his research findings. He also serves as a reviewer for multiple scientific journals such as Cells, International Journal of Molecular Sciences, Journal of Clinical medicine, and Biomolecules.In addition to his research and teaching duties, Dr. Saliba is deeply involved in supervising doctoral and master's students in physiological and pathophysiological sciences. He is recognized for his pedagogical skills, having also undergone training in medical pedagogy.Dr. Saliba has been honored with several international awards for his scientific contributions, including the International Union of Physiological Sciences (IUPS) Award and multiple awards from the Federation of the European Physiological Societies. His work and dedication to science are well-acknowledged in the academic community, underscoring his role as a key contributor to the field of medical sciences.

Education

Diplôme Université Pays Année
Doctorat - Physiologie et physiopathologie Sorbonne Université France 2012
Master Recherche Biologie Santé - Option Physiologie et Physiopathologie Saint Joseph University of Beyrouth Liban 2008
Maitrise ES Sciences, Biologie Option Animale Université Libanaise (UL) Liban 2007

Enseignement à l'USJ

Méthodologie de la Recherche

Domaine d’expertise

Médecine et Santé

Thématiques de recherche

Evaluation of the cellular and molecular aspects of the morphological and functional remodeling of the heart and kidney under stressful conditions, and determination of new therapeutic targets.
Research axes:
1- Heart: Cardiac dysfunction - Fibrosis - Senescence - Oxidative stress - Therapeutic targets
2- Kidney: Renal dysfunction - Fibrosis - Senescence - Oxidative stress - Therapeutic targets
3- Homeostatic disorders
4- Calcium signaling

Publications et communications

Amara J, Itani T, Hajal J, Bakhos JJ, Saliba Y,Aboushanab SA, Kovaleva EG, Fares N, Mondragon AC, Miranda JM. Circadian RhythmPerturbation Aggravates Gut Microbiota Dysbiosis in Dextran SulfateSodium-Induced Colitis in Mice. Nutrients. 2024 Jan 12;16(2):247. doi:10.3390/nu16020247. PMID: 38257139; PMCID: PMC10819604. https://pubmed.ncbi.nlm.nih.gov/38257139/

S N Hatem, J J Bakhos, Y Saliba, J Hajal, GAchkouty, A Semaan, N Fares, The anti-fibrotic effect of atrial natriureticpeptide depends on myocardial accumulation of the peptide in rat heart,European Heart Journal, Volume 44, Issue Supplement_2, November 2023,ehad655.3157, https://doi.org/10.1093/eurheartj/ehad655.3157


Rached G, Saliba Y*, Maddah D, Hajal J, Smayra V, Bakhos JJ,Groschner K, Birnbaumer L, Fares N*. TRPC3 Regulates Islet Beta-Cell InsulinSecretion. Adv Sci (Weinh). 2023 Feb;10(6):e2204846. doi:10.1002/advs.202204846. Epub 2023 Jan 15. PMID: 36642838; PMCID: PMC9951314. https://pubmed.ncbi.nlm.nih.gov/36642838/

Charbel Chalouhy, Nassim Fares, Youakim Saliba,Pedro Maria, Ahmed Aboumoouhamed, Marwan Kassis, Alexander Small, and JustinLoloi. Redox imbalance and mapk activation mediates pneumoperitoneum-inducedkidney injury during minimally invasive surgery. Journal of Urology, 1 Apr 2023.https://doi.org/10.1097/JU.0000000000003272.03


Ismail A, Saliba Y, Fares N. Early Development of CardiacFibrosis in Young Old-Father Offspring. Oxid Med Cell Longev. 2022 Sep19;2022:8770136. doi: 10.1155/2022/8770136. PMID: 36193084; PMCID: PMC9526616. https://pubmed.ncbi.nlm.nih.gov/36193084/

Layoun H*, Hajal J*, Saliba Y*, Smayra V, Habr B, Fares N.Pirfenidone mitigates TGF-β1-mediated fibrosis in an idiopathic inflammatorymyositis-associated interstitial lung disease model. Cytokine. 2022Jun;154:155899. doi: 10.1016/j.cyto.2022.155899. Epub 2022 Apr 30. PMID:35504143. https://pubmed.ncbi.nlm.nih.gov/35504143/

Habr B*, Saliba Y*, Hajal J, Smayra V,Riachy M, Fares N. Hydrocortisone mitigates ICU-AW by fine-tuning of muscleatrophic and hypertrophic signaling pathways in a sepsis model with limbimmobilization. Life Sci. 2020 Nov 15;261:118366. doi:10.1016/j.lfs.2020.118366. Epub 2020 Aug 29. PMID: 32871182. https://pubmed.ncbi.nlm.nih.gov/32871182/

Achkar A, Saliba Y, Fares N. DifferentialGender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes inAging Mice. Oxid Med Cell Longev. 2020 May 23;2020:8282157. doi:10.1155/2020/8282157. PMID: 32566103; PMCID: PMC7267867. https://pubmed.ncbi.nlm.nih.gov/32566103/

Chacar S, Hajal J*, Saliba Y*, Bois P,Louka N, Maroun RG, Faivre JF, Fares N. Long-term intake of phenolic compoundsattenuates age-related cardiac remodeling. Aging Cell. 2019 Apr;18(2):e12894.doi: 10.1111/acel.12894. Epub 2019 Jan 24. PMID: 30680911; PMCID: PMC6413651. https://pubmed.ncbi.nlm.nih.gov/30680911/

Beaini S*, Saliba Y*, Hajal J, Smayra V,Bakhos JJ, Joubran N, Chelala D, Fares N. VEGF-C attenuates renal damage insalt-sensitive hypertension. J Cell Physiol. 2019 Jun;234(6):9616-9630. doi:10.1002/jcp.27648. Epub 2018 Oct 30. PMID: 30378108. https://pubmed.ncbi.nlm.nih.gov/30378108/

Saliba Y, Jebara V, Hajal J,Maroun R, Chacar S, Smayra V, Abramowitz J, Birnbaumer L, Farès N. TransientReceptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3Signaling Pathway Critically Regulates Myocardial Fibrosis. Antioxid RedoxSignal. 2019 Jun 1;30(16):1851-1879. doi: 10.1089/ars.2018.7545. Epub 2018 Nov29. PMID: 30318928; PMCID: PMC6486676. https://pubmed.ncbi.nlm.nih.gov/30318928/

Saliba Y, Bakhos JJ, Itani T,Farès N. An optimized protocol for purification of functional islets ofLangerhans. Lab Invest. 2017 Jan;97(1):70-83. doi: 10.1038/labinvest.2016.123.Epub 2016 Nov 28. PMID: 27892930. https://pubmed.ncbi.nlm.nih.gov/27892930/

Saliba Y, Karam R,Smayra V, Aftimos G, Abramowitz J, Birnbaumer L, Farès N. Evidence of a Rolefor Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in RenalFibrosis. J Am Soc Nephrol. 2015 Aug;26(8):1855-76. doi:10.1681/ASN.2014010065. Epub 2014 Dec 5. PMID: 25479966; PMCID: PMC4520158. https://pubmed.ncbi.nlm.nih.gov/25479966/


Saliba Y, Keck M, Marchand A, Atassi F,Ouillé A, Cazorla O, Trebak M, Pavoine C, Lacampagne A, Hulot JS, Farès N,Fauconnier J, Lompré AM. Emergenceof Orai3 activity during cardiac hypertrophy. Cardiovasc Res. 2015 Mar1;105(3):248-59. doi: 10.1093/cvr/cvu207. Epub 2014 Sep 11. PMID: 25213556;PMCID: PMC4351368. (selected as Editor’s Choice) https://pubmed.ncbi.nlm.nih.gov/25213556/


Hajje G*, Saliba Y*, Itani T, Moubarak M,Aftimos G, Farès N. Hypothyroidism and its rapid correction alter cardiacremodeling. PLoS One. 2014 Oct 15;9(10):e109753. doi:10.1371/journal.pone.0109753. PMID: 25333636; PMCID: PMC4198123. https://pubmed.ncbi.nlm.nih.gov/25333636/


Saliba Y, MougenotN, Jacquet A, Atassi F, Hatem S, Farès N, Lompré AM. A new method of ultrasonicnonviral gene delivery to the adult myocardium. J Mol Cell Cardiol. 2012Dec;53(6):801-8. doi: 10.1016/j.yjmcc.2012.07.016. Epub 2012 Aug 3. PMID:22884737. https://pubmed.ncbi.nlm.nih.gov/22884737/


Liens utiles

https://www.linkedin.com/in/youakim-saliba/

Prix et distinctions

Prix de voyage pour participer au Joint Meeting of the FEPS and the Baltic Physiological Socities