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Youakim SALIBA

Youakim SALIBA

Associate Professor

Faculty of Medicine – Coordinateur des enseignements Laboratoire de physiologie et physiopathologie

+961 (1) 421 000 ext 6828 youakim.saliba@usj.edu.lb

Dr. Youakim Saliba is an academic and researcher in the field of health sciences. He is currently engaged as an Associate Professor at the Faculty of Medicine of the Saint Joseph University of Beirut, where he has been serving since 2012. Dr. Saliba also holds an academic editor position at the journal Cardiovascular Therapeutics since 2022.Dr. Saliba's educational background is extensive. He earned his PhD in 2012 from Sorbonne Université, specializing in Physiology and Pathophysiology with a thesis on the identification of STIM1 partners in normal and hypertrophied hearts. He completed his Master's in Research in Biology - Health, specializing in Physiology, from USJ in 2008, and prior to that, a Bachelor's degree in Biological Sciences from the Lebanese University in 2007.His research focuses on cardiovascular physiology and pathophysiology, contributing significantly to the understanding of cardiac and renal fibrosis mechanisms. Dr. Saliba is a prolific author, having published numerous articles in high-impact journals, and actively participates in international scientific conferences, presenting his research findings. He also serves as a reviewer for multiple scientific journals such as Cells, International Journal of Molecular Sciences, Journal of Clinical medicine, and Biomolecules.In addition to his research and teaching duties, Dr. Saliba is deeply involved in supervising doctoral and master's students in physiological and pathophysiological sciences. He is recognized for his pedagogical skills, having also undergone training in medical pedagogy.Dr. Saliba has been honored with several international awards for his scientific contributions, including the International Union of Physiological Sciences (IUPS) Award and multiple awards from the Federation of the European Physiological Societies. His work and dedication to science are well-acknowledged in the academic community, underscoring his role as a key contributor to the field of medical sciences.

Education

Degree University Country Year
PhD in Physiology and Pathophysiology Sorbonne Université France 2012
Master Biology Health - Option Physiology and Pathophysiology Saint Joseph University of Beyrouth Lebanon 2008
Maîtrise ES Sciences Université Libanaise (UL) Lebanon 2007

Teaching at USJ

Méthodologie de la Recherche

Areas of expertise

Medecine and Health

Research themes

Evaluation of the cellular and molecular aspects of the morphological and functional remodeling of the heart and kidney under stressful conditions, and determination of new therapeutic targets.
Research axes:
1- Heart: Cardiac dysfunction - Fibrosis - Senescence - Oxidative stress - Therapeutic targets
2- Kidney: Renal dysfunction - Fibrosis - Senescence - Oxidative stress - Therapeutic targets
3- Homeostatic disorders
4- Calcium signaling

Publications and communications

Amara J, Itani T, Hajal J, Bakhos JJ, Saliba Y, Aboushanab SA, Kovaleva EG, Fares N, Mondragon AC, Miranda JM. Circadian Rhythm Perturbation Aggravates Gut Microbiota Dysbiosis in Dextran Sulfate Sodium-Induced Colitis in Mice. Nutrients. 2024 Jan 12;16(2):247. doi: 10.3390/nu16020247. PMID: 38257139; PMCID: PMC10819604. https://pubmed.ncbi.nlm.nih.gov/38257139/

S N Hatem, J J Bakhos, Y Saliba, J Hajal, G Achkouty, A Semaan, N Fares, The anti-fibrotic effect of atrial natriuretic peptide depends on myocardial accumulation of the peptide in rat heart, European Heart Journal, Volume 44, Issue Supplement_2, November 2023, ehad655.3157, https://doi.org/10.1093/eurheartj/ehad655.3157


Rached G, Saliba Y*, Maddah D, Hajal J, Smayra V, Bakhos JJ, Groschner K, Birnbaumer L, Fares N*. TRPC3 Regulates Islet Beta-Cell Insulin Secretion. Adv Sci (Weinh). 2023 Feb;10(6):e2204846. doi: 10.1002/advs.202204846. Epub 2023 Jan 15. PMID: 36642838; PMCID: PMC9951314. https://pubmed.ncbi.nlm.nih.gov/36642838/

Charbel Chalouhy, Nassim Fares, Youakim Saliba, Pedro Maria, Ahmed Aboumoouhamed, Marwan Kassis, Alexander Small, and Justin Loloi. Redox imbalance and mapk activation mediates pneumoperitoneum-induced kidney injury during minimally invasive surgery. Journal of Urology, 1 Apr 2023. https://doi.org/10.1097/JU.0000000000003272.03


Ismail A, Saliba Y, Fares N. Early Development of Cardiac Fibrosis in Young Old-Father Offspring. Oxid Med Cell Longev. 2022 Sep 19;2022:8770136. doi: 10.1155/2022/8770136. PMID: 36193084; PMCID: PMC9526616. https://pubmed.ncbi.nlm.nih.gov/36193084/

Layoun H*, Hajal J*, Saliba Y*, Smayra V, Habr B, Fares N. Pirfenidone mitigates TGF-β1-mediated fibrosis in an idiopathic inflammatory myositis-associated interstitial lung disease model. Cytokine. 2022 Jun;154:155899. doi: 10.1016/j.cyto.2022.155899. Epub 2022 Apr 30. PMID: 35504143. https://pubmed.ncbi.nlm.nih.gov/35504143/

Habr B*, Saliba Y*, Hajal J, Smayra V, Riachy M, Fares N. Hydrocortisone mitigates ICU-AW by fine-tuning of muscle atrophic and hypertrophic signaling pathways in a sepsis model with limb immobilization. Life Sci. 2020 Nov 15;261:118366. doi: 10.1016/j.lfs.2020.118366. Epub 2020 Aug 29. PMID: 32871182. https://pubmed.ncbi.nlm.nih.gov/32871182/

Achkar A, Saliba Y, Fares N. Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice. Oxid Med Cell Longev. 2020 May 23;2020:8282157. doi: 10.1155/2020/8282157. PMID: 32566103; PMCID: PMC7267867. https://pubmed.ncbi.nlm.nih.gov/32566103/

Chacar S, Hajal J*, Saliba Y*, Bois P, Louka N, Maroun RG, Faivre JF, Fares N. Long-term intake of phenolic compounds attenuates age-related cardiac remodeling. Aging Cell. 2019 Apr;18(2):e12894. doi: 10.1111/acel.12894. Epub 2019 Jan 24. PMID: 30680911; PMCID: PMC6413651. https://pubmed.ncbi.nlm.nih.gov/30680911/

Beaini S*, Saliba Y*, Hajal J, Smayra V, Bakhos JJ, Joubran N, Chelala D, Fares N. VEGF-C attenuates renal damage in salt-sensitive hypertension. J Cell Physiol. 2019 Jun;234(6):9616-9630. doi: 10.1002/jcp.27648. Epub 2018 Oct 30. PMID: 30378108. https://pubmed.ncbi.nlm.nih.gov/30378108/

Saliba Y, Jebara V, Hajal J, Maroun R, Chacar S, Smayra V, Abramowitz J, Birnbaumer L, Farès N. Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis. Antioxid Redox Signal. 2019 Jun 1;30(16):1851-1879. doi: 10.1089/ars.2018.7545. Epub 2018 Nov 29. PMID: 30318928; PMCID: PMC6486676. https://pubmed.ncbi.nlm.nih.gov/30318928/

Saliba Y, Bakhos JJ, Itani T, Farès N. An optimized protocol for purification of functional islets of Langerhans. Lab Invest. 2017 Jan;97(1):70-83. doi: 10.1038/labinvest.2016.123. Epub 2016 Nov 28. PMID: 27892930. https://pubmed.ncbi.nlm.nih.gov/27892930/

Saliba Y, Karam R, Smayra V, Aftimos G, Abramowitz J, Birnbaumer L, Farès N. Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis. J Am Soc Nephrol. 2015 Aug;26(8):1855-76. doi: 10.1681/ASN.2014010065. Epub 2014 Dec 5. PMID: 25479966; PMCID: PMC4520158. https://pubmed.ncbi.nlm.nih.gov/25479966/


Saliba Y, Keck M, Marchand A, Atassi F, Ouillé A, Cazorla O, Trebak M, Pavoine C, Lacampagne A, Hulot JS, Farès N, Fauconnier J, Lompré AM. Emergence of Orai3 activity during cardiac hypertrophy. Cardiovasc Res. 2015 Mar 1;105(3):248-59. doi: 10.1093/cvr/cvu207. Epub 2014 Sep 11. PMID: 25213556; PMCID: PMC4351368. (selected as Editor’s Choice) https://pubmed.ncbi.nlm.nih.gov/25213556/


Hajje G*, Saliba Y*, Itani T, Moubarak M, Aftimos G, Farès N. Hypothyroidism and its rapid correction alter cardiac remodeling. PLoS One. 2014 Oct 15;9(10):e109753. doi: 10.1371/journal.pone.0109753. PMID: 25333636; PMCID: PMC4198123. https://pubmed.ncbi.nlm.nih.gov/25333636/


Saliba Y, Mougenot N, Jacquet A, Atassi F, Hatem S, Farès N, Lompré AM. A new method of ultrasonic nonviral gene delivery to the adult myocardium. J Mol Cell Cardiol. 2012 Dec;53(6):801-8. doi: 10.1016/j.yjmcc.2012.07.016. Epub 2012 Aug 3. PMID: 22884737. https://pubmed.ncbi.nlm.nih.gov/22884737/


Awards and distinctions

Prix de voyage pour participer au Joint Meeting of the FEPS and the Baltic Physiological Socities