Aspects physiopathologiques du rôle du microbiote intestinal et de l’inflammation dans les troubles de l’humeur, et leurs implications thérapeutiques

Description :
Study population: Patients in a current episode of MDD admitted at Hôtel-Dieu de France University Hospital, as determined by the Mini International Neuropsychiatric Interview (MINI) per DSM-IV criteria, and not currently taking any antidepressant medication.•Necessary inclusion and exclusion and exclusion criteria will be applied. •Healthy individuals and controls will be recruited: A group of controls matched for number, age, gender, diet, sociodemographic characteristics, life circumstances.•Informed consent: Subjects will have a face-to-face meeting with the physician who will explain the study. If in agreement, the subject will be asked to sign and complete the consent form. •Double-blinded observational study•Relevant surveys for both controls and patients will be used to evaluate: eating habits using the Mediterranean diet questionnaire, sociodemographic characteristics, other comorbidities, medications (antidepressant and others), history of psychiatric treatment, GI disorders, BMI.•Metagenomics analysis will be performed on fecal samples, inflammatory state evaluation on blood samples, both for depressed and control patents•Effect of probiotic intake will be evaluated in probiotic vs placebo groups•In parallel, metagenomics analysis, inflammatory state evaluation and effect of probiotic intake will be performed on mice using the unpredictable chronic mild stress depressive model.

Titulaire :
FARES Nassim

Contact USJ :
nassim.fares@usj.edu.lb

Chercheur(s) :
Dr Nassim FARES, Dr Sami RICHA, M. Marc BOUJI, Pr Rayane Rafei, Mlle Nour Daboussi, M. Youakim SALIBA, Pr Dolla KARAM SARKIS

Projet présenté au CR, le : 02/01/2023

Projet achevé auprès du CR : 31/12/2025