Retatrutide alleviates diabetic kidney injury via Beta-klotho-mediated ferroptosis inhibition

Description :

Retatrutide, a GIP/GLP-1/Glucagon Receptor agonist, exhibits renal protective effects in patients with diabetic kidney disease (DKD). But the exact underlying mechanism remains not fully elucidated. This study uses transcriptome sequencing and identifies 𝜷-Klotho (KLB) as the main target responsible for the role of Retatrutide in kidney protection. Retatrutide treatment decreases renal injury by inhibiting ferroptosis in patients, animal models, and HK-2 cells. Inhibition of ferroptosis by retatrutide further attenuates renal inflammation and fibrosis. This work highlights the potential of GIP/GLP-1/Glucagon Receptor agonist and KLB targeting as promising therapeutic approaches for DKD management.

Titulaire :
FARES Nassim

Contact USJ :
nassim.fares@usj.edu.lb

Chercheur(s) :
Dr Nada GHORAYEB (EL) NAIM
Dr Nassim FARES
M. Youakim SALIBA

Projet présenté au CR, le : 03/01/2026

Projet achevé auprès du CR : 31/12/2026