Modulating Autonomic and Cortical Dysregulation in Fibromyalgia: Randomized Controlled Trials of Heart Rate Variability Biofeedback and EEG Neurofeedback

Description :

This research project investigates innovative, non-pharmacological approaches for the management of fibromyalgia, a chronic pain condition affecting millions of individuals worldwide, particularly women. Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances, and cognitive difficulties, often linked to dysregulation of the autonomic nervous system and altered brain activity. Current treatments frequently provide limited relief, highlighting the need for alternative therapeutic strategies. The study consists of two randomized controlled trials evaluating the effectiveness of heart rate variability biofeedback (HRV-BF) and EEG neurofeedback. These techniques aim to improve the body’s ability to regulate physiological processes such as heart rate, breathing, and brain activity through real-time feedback and training. Participants will undergo clinical assessments, complete validated questionnaires on pain, fatigue, sleep, and quality of life, and take part in physiological measurements including heart rate variability, brainwave recordings (EEG), and blood tests for inflammatory markers such as interleukin-6. Interventions will combine supervised sessions at the laboratory with home-based practice using wearable devices and mobile applications. By integrating clinical outcomes with physiological biomarkers, this study seeks to better understand the mechanisms underlying fibromyalgia and to identify objective indicators of treatment response. Ultimately, the project aims to contribute to the development of accessible, personalized, and non-invasive therapies for chronic pain management.

Titulaire :
KOBAITER MAARRAWI Sandra

Contact USJ :
sandra.kobaitermaarrawi@usj.edu.lb

Chercheur(s) :
Dr Joseph MAARRAWI
Dr Halim ABBOUD
Dr Nelly ZIADE ZOGHBI
Dr Hady JALKH (EL)
Mlle Tala TANNOUS

Projet présenté au CR, le : 15/05/2026

Projet achevé auprès du CR : 30/06/2029