Remineralization of Enamel White Spot Lesions: Effects of the Self-Assembling Peptide P11-4, Casein Phosphopeptide–Amorphous Calcium Phosphate, and Fluoride Varnish: An Experimental and Prospective Clinical Comparative Study with Up to One-Year Follow-Up.

Description :

Dental caries in children, beginning with enamel demineralization, is a major public health concern among the most prevalent chronic conditions worldwide, impacting quality of life and posing a substantial challenge in pediatric dentistry. Preventing the progression of early enamel demineralization, initially appearing as white spot lesions (WSLs), through non-invasive therapeutic strategies is a key priority in modern dental care. Fluoride varnish application is a well-established method promoting enamel remineralization by enhancing fluoroapatite formation. However, its action remains largely passive, highly dependent on consistency of application and limited to superficial layers of the enamel lesion, without effectively reaching deeper structures. In contrast, the Curodont Repair® gel, incorporating self-assembling peptides, is gaining attention for its biomimetic regenerative mechanism. It is designed to penetrate the core of early WSLs. Upon application, the peptide self-assembles into a three-dimensional matrix in the presence of saliva, guiding the deep remineralization of enamel through deposition of calcium and phosphate ions, effectively mimicking natural enamel formation. Despite growing use of both approaches, comparative data regarding their specific efficacy, and the potential synergistic effect of their combined application, remain limited in the current literature. Therefore, this research will evaluate the effectiveness of four approaches: Fluoride varnish (Fluorodose ®) as a control group, self-assembling peptide P11-4 (Curodont Repair®) alone, CPP-ACP (Tooth Mousse®) alone, and the combination of self-assembling peptide P11-4 (Curodont Repair®) and CPP-ACP (Tooth Mousse®) inpromoting enamel remineralization in children. The results aim to support clinical decision-making based on reliable evidence tailored to the specific needs of pediatric patients.

Titulaire :
CHEDID Nada

Contact USJ :
nada.chedid@usj.edu.lb

Chercheur(s) :
Pr Nada CHEDID
Dr Maria KHOURY (EL) ABBOUD

Projet présenté au CR, le : 01/05/2026

Projet achevé auprès du CR : 31/05/2029