Lateral ridge augmentation using cross-linked or peritoneum collagen membrane with a composite allograft-xenograft mix: a randomized pilot clinical trial

Description :

This study is a randomized pilot clinical trial investigating lateral ridge augmentation using either a cross-linked collagen membrane or a porcine peritoneum-derived membrane, both in combination with a composite allograft-xenograft bone graft. Conducted at Saint Joseph University of Beirut, the study aims to compare the effectiveness of these two resorbable membranes in guided bone regeneration (GBR). The primary objective is to assess linear and volumetric bone width changes clinically and radiographically. Secondary objectives include evaluating ridge height gain, soft tissue healing, and performing histological and histomorphometric analyses. The null hypothesis assumes no difference in bone width changes between membrane types, while the alternative hypothesis suggests otherwise. The study involves single-blinded randomization, with patients undergoing pre-operative preparation, CBCT imaging, and guided surgical intervention. Bone width is measured at multiple points pre- and post-operatively, and at six months, re-entry procedures and biopsies are performed.