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Marie-Hélène GANNAGE YARED

Directeur - Thèses
Coordinateur des stages des internes - Endocrinologie

Chargé de Cours - Vacataire

Faculté de médecine (FM)

(+961) 1 421 000 ext mariehelene.yared@usj.edu.lb

Marie-Hélène Gannagé-Yared est professeur dendocrinologie à l'Université Saint-Joseph de Beyrouth. Elle est actuellement chef du département d'endocrinologie à la Faculté de médecine de l'Université Saint-Joseph et chef de la division d'endocrinologie et métabolisme à l'hôpital Hôtel-Dieu de France à Beyrouth. Elle est l'auteur de plus de 70 articles publiés dans des revues médicales indexées


• DEA
• Endocrinologue
• Endocrinologue
• Docteur en medecine


Médecine et Santé

Vitamine D PTH Lipides diabete Pediatrie

1.Halaby G, Karam J, Jambart S, Aydenian H, Zankoul R, Gannagé MH Intérêt du dosage du peptide C dans le diabète. Journal Méd Lib 1989 24: 29-34. 2.J Parma, Stengel D, Gannagé MH, Poyard M, Barouki R, J Hanoune. Sequence of a human brain adenylyl cyclase partial cDNA Biochemical Biophysical Resarch Communication, 1991; 179: 455-462 3.Stengel D, J Parma, Gannagé MH, Roeckel N, Mattei MG, Barouki R, J Hanoune. Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. Human Genet. 1992 ; 90; 126-130. 4.Nemr E, Medlej R, Atallah C, Gannagé MH, Jambart S, Halaby G. Hyperparathyroidie primaire: Experience de l’Hotel-Dieu. Etude clinique de 28 cas. Journal Méd Lib 1994; 42:56-58. 5.Gannagé MH, Haddad F, Jambart S, Atallah C, Halaby G. Intérêt du dosage des anticorps antirécepteurs à la TSH. Journal Méd Lib 1996; 44:134-137. 6.Gannagé MH, Maacaron C, Okais N, Halaby G. Adénome hypophysaire à TSH: à propos d’un cas. Journal Méd Lib 1997; 45: 97-101. 7.Abboud B, Jambart S, Fabre V, Gannagé MH, Farah P. Parathyroidectomie sous anesthesie locale. Deux premiers cas au Liban et revue de la littérature. Journal Méd Lib 1997; 45:107-11. 8.Gannagé MH, Abi-Karam G, Nasr F, Awada H. Osteomalacia secondary to coeliac disease, primary hyperparathyroidism and Graves disease. Am J Medical Sci 1998; 315: 136-139. 9.Gannagé-Yared MH, Khneisser I, Salem N, Gouyette A, Loiselet J, Halaby G, Massade L. Glutathion et glutathion-S-transférase sanguins et leucocytaires: relation avec la cholestérolémie chez des volontaires sains. Ann Biol Clin 1998; 56: 321-7. 10.Gannagé-Yared MH, Brax H, Asmar A, Tohmé A. Statut vitaminique D des sujets âgés. Etude de la population libanaise. La Presse Médicale. 1998; 27:900-4. 11.Gannagé-Yared MH. Immunogénétique et nouveautés thérapeutiques dans le diabète de type I. Journal Méd Lib. 1999; 47: 139-143. 12.Khallouf E, Gannagé-Yared MH, Melki I, Féghali D, Akatchérian C. Variations de l’insulin-growth factor 1 (IGF 1) avec le poids de naissance au premier jour de vie. Abstract. Journal Méd Lib. 1999; 47: 70-71. 13. Gannagé-Yared MH, Saadé C, Abboud B, Nasnas R, Halaby G. Hyperthyroidism, primary hyperparathyroidism, and vitamin D deficiency. Endocrine Practice. 1999; 5: 205-207. 14. Gannagé-Yared MH, Chemali R, Yaacoub N, Halaby G. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000; 15: 1856-62. 15. Gannagé-Yared MH, Atallah C, Jambart S. Hypertension artérielle, ménopause et traitement hormonal substitutif. Journal Méd Lib 2000; 48: 387-391. 16. Gannagé-Yared MH, Tohmé A, Halaby G. L’hypovitaminose D de nos jours: un problème mondial majeur de santé publique. La presse médicale 2001; 30: 653-8. 17. Gannagé-Yared MH, Azoury M, Mansour I, Baddoura R, Halaby G, Naaman R. Effects of a short-term Calcium and vitamin D treatment on serum cytokines, bone markers, insulin and lipid concentrations in healthy postmenopausal women. J Endocrino Invest 2003; 26:748-753. 18. Mégarbané A, Gannagé-Yared MH, Khalifé AA, Fabre M. Primary hypergonadotropic hypogonadism, partial alopecia, and mullerian hypoplasia. Report of a second family with additional findings. Am J Med Genetics 2003; 119: 214-7. 19. Ghassan M, Alexandre N, Joseph W, Fadi H, Marie-Hélène GY. Osteoporosis a disease for all; in Lebanon. Clin Calcium 2004;14:116-22. 20. Gannagé-Yared MH, Azar RR, Amm-Azar M, Khalifé S, Germanos-Haddad M, Neemtallah R, Halaby G. Pravastatin Does Not Affect Insulin Sensitivity and Adipocytokines Levels in Healthy Non-Diabetic Patients. Metabolism Clinical and Experimental 2005; 54: 947-951. 21. Gannagé-Yared MH, Dodé C, Ghanem I, Choueiry E, Jalkh N, Hardelin JP, Megarbané A. Coexistence of Kallman syndrome and complete androgen insensitivity in the same patient. Eur J Endocrinol 2005; 152: 813-817 22. Gannagé-Yared MH, Chemali R, Sfeir C, Maalouf G, Halaby G. Dietary calcium and vitamin D intake in an adult Middle Eastern population: food sources and relation to lifestyle and PTH. Int J Vitam Nutr Res 2005;75:281-9. 23. Maalouf G, Wehbe J, Nehme A, Moucharafieh R, Gannagé-Yared MH, Chidiac RM, Yaghi Y. Characteristics of hip fracture in Lebanese population. Osteoporosis Int 2005 16 Suppl 3. Abstract 24. Gannagé-Yared MH, Fares F, Semaan M, Khalifé S, Jambart S. Circulating osteoprotegerin is correlated with lipid profile, insulin sensitivity, adiponectin and sex steroids in an aging male population. Clinical Endocrinology 2006; 64: 652-658. 25. Gannagé-Yared MH, Khalifé S, Semaan M, Fares F, Jambart S, Halaby G. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non diabetic elderly men. Eur J Endocrinol 2006;155:167-76. 26. Azar R, Sarkis A, Badaoui G, Gannagé- Yared MH, Amm-Azar M, Salame E, Germanos M, Kassab R. Effect of arterial inflammation on adiponectin and leptin levels. New insights on the link between the immune and the metabolic system Clinical Endocrinology. 2006; 65: 712-6. 27.Maalouf G, Wehbe J, Farah G, Sawan D, Tannous Z, Nehme A, Chidiac RM, Gannage Yared MH, Jalkh S. Phalangeal osteosonogrammetry age-related changes and assessment of a Lebanese reference population. Bone. 2007; 40:1650-4. 28. Maalouf G, Maalouf NM, Schaaf N, Zebaze RM, Nehme A, Tannous Z, Wehbe J, Adib G, Gannagé-Yared MH, Seeman E. The spinal curvature irregularity index independently identifies vertebral fractures. Osteoporos Int. 2007;18:279-83. 29.Gannagé-Yared MH, Slaba S, Rizk T, Chidiac-Wehbé RM.Use ofdesmopressin as an alternative to CRH during inferior petrosal sinus sampling in a child with Cushings disease. J Endocrino Invest 2007;30:434-8. 30.Maalouf G, Gannagé-Yared MH, Ezzedine J, Larijani B, Badawi S, Rached A, Zakroui L, Masri B, Azar E, Saba E, Nammari R, Adib G, Abou Samra H, Alrawi Z,Salman S, El Muntasser K, Tarseen R, El Kharousi W, Al-Lamki M, Alothman AN,Almarzook N, El Dessouki M, Sulaimani R, Saleh J, Suhaili AR, Khan A, Delmas P, Seeman E. East and North Africa consensus on osteoporosis. J Musculoskelet Neuronal Interact. 2007; 7:131-43. 31. Gannagé-Yared MH, Yaghi C, Habre B, Khalifé S, Noun R, Germanos-Haddad M, Trak-Smayra V. Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines and C-reactive protein in obese and non obese young individuals: results from both crossectionnal and interventional study. Eur J Endocrinol 2008; 158: 353-359 32. Haddad F, Maalouly G, Asmar G, Nemnoum R, Jammal M, Ghannage-Yared MH. Hypothyroïdie haute révélant une localisation hypophysaire d’une forme granulomateuse de maladie de Wegener La revue de médecine interne : 2008 : 29 ; 146. 33. Trak-Smayra V, Dargere D, Noun R, Albuquerque M, Yaghi C, Gannagé-Yared MH, Bedossa P, Paradis V. Serum proteomic profiling of obese patients: correlation with pathology and evolution after bariatric surgery. Gut 2009; 58:825-32 34. Gannagé-Yared MH, Maalouf G, Khalifé S, Challita S, Yaghi Y, Ziadé N , Chalfoun A, Norquist J,. Chandler J. Prevalence and predictors of vitamin D inadequacy amongst lebanese osteoporotic women. Br J Nutr 2009; 101: 487-491. 35. Gannagé-Yared MH, Abboud B, Amm-azar A, Saab A, Khalife S, Halaby G, Atallah C, Medlej R, and Jambart S. Predictors of intraoperative parathyroid hormone decline in subjects operated from primary hyperparathyroidism by minimally invasive parathyroidectomy . J Endocrinol Invest 2009; 32: 160-164. 36. Chedid R, Gannagé-Yared MH, Khalifé S, Halaby G Zoghbi F. Impact of different Metabolic Syndrome (MetS) classifications on the MetS prevalence in a young Middle-Eastern population. Metabolism 2009; 58: 746-752 (Copremier auteur avec Rima Chedid) 37.Gannagé-Yared MH, Chedid R, Khalife S, Azzi E, Zoghbi F, Halaby G, Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population. Eur J Endocrinol 2009; 160: 965-71. 38. Abifadel M, Rabès JP, Jambart S, Halaby G, Gannagé-Yared MH, Sarkis A, Beaino G, Varret M, Salem N, Corbani S, Aydénian H, Junien C, Munnich A, Boileau C. The molecular basis of familial hypercholesterolemia in Lebanon: Spectrum of LDLR mutations and role of PCSK9 as a modifier gene. Hum Mutat 2009; 30: E682-91. 39. Chedid R, Zoghbi F, Halaby G, Gannagé-Yared MH. Serum uric acid in relation with the Metabolic Syndrome components, insulin sensitivity and Adiponectin levels in Lebanese university students. J Endocrinol Invest 2011; 3: 153-7. 40. Gannagé-Yared MH, Chedid R, Halaby G. Vitamin D status in Lebanese university students. J Med Liban 2010; 58: 191-194. 41. Gannagé-Yared MH, Chedid R, Abs L. Relation between androgens and cardiovascular risk factors in a young population. Clin Endocrinol (Oxf) 2011 : 74:720-5. 42. Farra C, Awwad J, Fadlallah A, Sebaly G, Hage G, Souaid M, Ashkar H, Medlej R, Gannageh MH, Halaby G. Genetics of autoimmune thyroid disease in the Lebanese population. J Community Genet. 2012 Mar 6. [Epub ahead of print] 43. Gannagé-Yared MH, Klammt J, Chouery E, Corbani S, Mégarbané H, Abou Ghoch J, Choucair N, Pfäffle R, Megarbané A. Homozygous mutation of the Insulin Growth Factor 1 Receptor gene in a patient with severe intrauterine, post natal growth failure and congenital malformations. Eur J Endocrinol 2012;168:K1-7. 44. Gannagé-Yared MH, Farès C, Ibrahim T, Rahal ZA, Elias M, Chelala D. Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients. Metabolism. 2013; 62:1416-22. 45. Kabbara R, Ziade F, Gannagé-Yared MH. Prevalence and etiology of menstrual disorders among Lebanese University Students Int J Gynaecol Obstet. 2014;126:177-8 46. Gannagé-Yared MH, Helou E, Zaraket V, Abi Akl S, Antonios L, Moussalli ML, Wakim S. Serum 25 hydroxyvitamin D in employees of a Middle Eastern university hospital 2014 J Endocrinol Invest 2014;37: 541-6 47. Brand JS, Rovers MM, Yeap BB, Schneider HJ, Tuomainen TP, Haring R, Corona Gannagé-Yared MH, Undén AL, Hautanen A, Goncharov NP, Kumanov P, Chubb SA, Almeida OP, Wittchen HU, Klotsche J, Wallaschofski H, Völzke H, Kauhanen J, Salonen JT, Ferrucci L, van der Schouw YT. Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies. PLoS One. 2014;9 (7) 48. Gannagé-Yared MH, Makrythanasis P, Chouery E, Sobacchi C, Antonarakis S, Hamamy H, Mégarbané A. Exome sequencing reveals a mutation in DMP1 in a family with familial sclerosing bone dysplasia. Bone 2014; 68: 142-5. 49. Gannagé-Yared MH, Farah V, Chahine E, Balech N, Ibrahim T, Asmar N, Barakett-Hamadé V, Jambart S.Distribution and correlates of non-high-density lipoprotein cholesterol and triglycerides in Lebanese school children. J Clin Lipidol. 2016;10:378-85. 50. Hajj A, Chedid R, Chouery E, Megarbané A, Gannagé-Yared MH. Relationship between vitamin D receptor gene polymorphisms, cardiovascular risk factors and adiponectin in a healthy young population. Pharmacogenomics. 2016;17:1675-1686. 51. Gannagé-Yared MH, Chahine E, Farah V, Toni Ibrahim T, Nadia Asmar N, Halaby G Serum insulin growth factor 1 in the Lebanese population and its relation to vitamin D and ferritin levels. Endocrine Practice 2017; 23: 391-398 52. Gannagé-Yared MH, Balech N, Farah V, Antar M, Saliba R, Chahine E. Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population. Int J Endocrinol. 2017;2017:6372964. 53. Gannagé-Yared MH, Sabbagh R, Chédid R. Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children. J Endocrinol Invest. 2018;41(9):1043-1049. 54. Younes N, Hajj MA, Bezdikian AJ, Gannagé-Yared MH. An epidemiological evaluation of pediatric fractures in Lebanon and analysis of associated risk factors: a cross-sectional study of 974 Lebanese children Arch Osteoporos. 2019 Jan 15;14(1):9. 55. Saadé C, Sleilaty G, Gannagé-Yared MH Longitudinal changes of lipid profile in the Lebanese pediatric population. Lipids Health Dis. 2019 Feb 11;18(1):48. 56. Younes N, Atallah M, Alam R, Chehade NH, Gannagé-Yared MH. HbA1c AND BLOOD PRESSURE MEASUREMENTS: RELATION WITH GENDER, BODY MASS INDEX, STUDY FIELD, AND LIFESTYLE IN LEBANESE STUDENTS. Endocr Pract. 2019 Nov;25(11):1101-1108. 57.Göpel E, Rockstroh D, Pfäffle H, Schlicke M, Pozza SB, Gannagé-Yared MH, Gucev Z, Mohn A, Harmel EM, Volkmann J, Weihrauch-Blüher S, Gausche R, Bogatsch H, Beger C, Klammt J, Pfäffle R. A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz165. 58. El Khoury R, Sleilaty G, Gannagé-Yared MH Prevalence of iron deficiency in Lebanese schoolchildren Eur J Clin Nutr. 2020 Aug;74(8):1157-1163. 59. Gannagé-Yared MH, Kallas-Chemaly MN, Sleilaty G. Establishment of reference values of serum PTH in a Middle-Eastern healthy population using 2nd and 3rd generation PTH assays. Int J Endocrinol. 2020 Feb 21;2020:6302861. 60. Gannagé-Yared MH, Younès N, Azzi AS, Sleilaty G. Comparison between Second- and Third-Generation PTH Assays during Minimally Invasive Parathyroidectomy (MIP). Int J Endocrinol 2020 Mar 16;2020:5230985. 61. Gannagé-Yared MH, Lahoud C, Younes N, Chedid R, Sleilaty G. Prevalence and status of Lipoprotein (a) among Lebanese school children. Sci Rep. 2020 Nov 26;10(1):20620. 62. Göpel E, Rockstroh D, Pfäffle H, Schlicke M, Pozza SB, Gannagé-Yared MH, Gucev Z, Mohn A, Harmel EM, Volkmann J, Weihrauch-Blüher S, Gausche R, Bogatsch H, Beger C, Klammt J, Pfäffle R. A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz165. 63. Ayoub C, Azar Y, Abou-Khalil Y, Ghaleb Y, Elbitar S, Halaby G, Jambart S, Gannagé-Yared MH, Yaghi C, Saade Riachy C, El Khoury R, Rabès JP, Varret M, Boileau C, El Khoury P, Abifadel M. Identification of a Variant in APOB Gene as a Major Cause of Hypobetalipoproteinemia in Lebanese Families. Metabolites. 2021 Aug 24;11(9):564. 64. Jambart I, Sleilaty G, Jambart S, Medlej R, Halaby G, Atallah C, Gannagé-Yared MH, Hajj G. Relative Fat Mass, a new tool for measuring obesity, could predict the complications of type 2 diabetes. Journal of Endocrinology and Disorders. 5(3): Journal of Endocronilogy and disorders. 2021 5(3) 65. Naous E, Boulos M, Sleilaty G, Achkar AA, Gannagé-Yared MH. Quality of life and other patient-reported outcomes in adult Lebanese patients with type 2 diabetes during COVID-19 pandemic. J Endocrinol Invest. 2022 Apr;45(4):763-772.. 66. Salameh C, Al Achkar A, El Boustany J, Sleilaty G, Gannagé-Yared MH. Reference intervals for thyroid stimulating hormone (TSH), Free Thyroxine (FT4) and total triodothyronine (TT3) in the Lebanese adult population En cours de revision dans Annals of Clinical Biochemestry 2022 Feb 27;45632221077865. 67. Ibrahim M, Ibrahim K, Chamseddine Z, Sleilaty G, Gannagé-Yared MH. COVID-19 – impact of the lockdown on the weight variation among the Lebanese population. Nutririon Clinique et metabolique 2022 68. Al Achkar A, Naous E, Salameh C, Cordahi CC, Germanos-Haddad M, Sleilaty G, Gannagé-Yared MH. Comparison of thyroid stimulating hormone, free thyroxine, total triiodothyronine, thyroglobulin and peroxidase antibodies measurements by two different platforms. Clin Chem Lab Med. 2022 May 6. 69. Azar Y, Gannagé-Yared MH, Naous E, Ayoub C, Abou Khalil Y, Chahine E, Elbitar S, Ghaleb Y, Boileau C, Varret M, El Khoury P, Abifadel M. Circulating PCSK9 Linked to Dyslipidemia in Lebanese Schoolchildren. Metabolites. 2022 May 31;12(6):504.. Cofirst and corresponding author 70. Gannagé-Yared MH, Naous E, Al Achkar A, Issa W, Sleilaty G, Barakett-Hamade V, Abifadel M. Lipid Parameters and Proprotein Convertase Subtilisin/Kexin Type 9 in Healthy Lebanese Adults. Metabolites. 2022 Jul 26;12(8):690. 71. Achkar AA, Mourad D, Naous E, Sleilaty G, Gannagé-Yared MH. Predictors of Serum TSH in a Healthy Adult Sample of the Lebanese Population Annals of thyroid research; Accepted: March 08, 2022; Published: March 15, 2022 72. Harkous D, Ghorayeb N, Gannagé-Yared MH. Prevalence and predictors of vitamin D deficiency in Lebanon: 2016-2022, before and during the COVID-19 outbreak. Endocrine. 2023 Dec;82(3):654-663. doi: 10.1007/s12020-023-03483-8. Epub 2023 Aug 19. PMID: 37597096.