Dr. Antoine MELKANE
Faculty of Medicine
Assistant professor
(+961) 1 421 000 ext 9612 antoine.melkane1@usj.edu.lb
Dr. Antoine Melkane is currently an Associate Professor in the Department of Otorhinolaryngology and Head and Neck Surgery at the Faculty of Medicine, Saint Joseph University. Dr. Melkane obtained his medical degree from the Faculty of Medicine in 2004. After completing his residency in Otorhinolaryngology at the Hôtel-Dieu de France University Hospital in 2009, he underwent specialized training in head and neck oncologic surgery at the Gustave Roussy Institute, University Paris XI, in Villejuif, France (2009-2012), followed by further training at the Karmanos Cancer Institute, Wayne State University, in Michigan, USA (2012-2013). He joined the Otorhinolaryngology department at Hôtel-Dieu de France in 2014, where he has since been actively involved in the care of patients with head and neck cancers. Dr. Melkane holds a Master’s in Surgical Sciences from University Paris XI (2012). His primary research interests focus on the involvement of HPV in oropharyngeal cancers and the role of sentinel lymph nodes in early-stage head and neck cancers. He has published more than 30 original articles in peer-reviewed journals. Dr. Melkane is a member of the scientific committee for the European Annals of Otorhinolaryngology, Head and Neck Surgery. He also serves as a reviewer for numerous other journals, including Head & Neck, Laryngoscope, and JAMA Otolaryngology–Head & Neck Surgery.
Highest degree : Medical Doctor (MD) with a Specialization Diploma in Head and Neck Surgery - Wayne State University - USA
+ Education
| Degrees | University | Country | Year |
|---|---|---|---|
| Diplôme Universitaire d'Education en Sciences de la Santé | Saint Joseph University of Beirut | Lebanon | 2024 |
| Head and Neck Surgery Fellowship | Wayne State University | Etats-Unis | 2013 |
| AFSA Oto-Rhino-Laryngologie et Chirurgie Cervico-Faciale | Université Paris-Sud (Paris 11) | France | 2012 |
| Master Sciences Chirurgicales | Université Paris-Sud (Paris 11) | France | 2012 |
| AFS Oto-Rhino-Laryngologie | Université Paris-Sud (Paris 11) | France | 2011 |
| Diplôme d'Université en Carcinologie Cervico-Faciale | Université Paris-Sud (Paris 11) | France | 2010 |
| Diplôme de Spécialisation en Otorhinolaryngologie | Saint Joseph University of Beirut | Lebanon | 2009 |
| Diplôme Universitaire de Microchirurgie | Saint Joseph University of Beirut | Lebanon | 2007 |
| Diplôme de Docteur en Médecine | Saint Joseph University of Beirut | Lebanon | 2004 |
+ Professionnal experience outside USJ
| Professional Experience | Organization | Start date | End date |
|---|---|---|---|
| Full time Practitionar | Hotel Dieu de France University Hospital | 01/03/2014 | 07/11/2024 |
| Clinical Consultant | Saint Charles Hospital | 01/11/2013 | 31/10/2018 |
| Part Time Practitionar | Bellevue Medical Center | 01/09/2013 | 31/08/2020 |
| Head & Neck Surgery Fellow | Karmanos Cancer Institute | 01/08/2012 | 31/07/2013 |
| Head & Neck Surgery Fellow | Gustave Roussy Institute | 01/05/2010 | 30/04/2012 |
+ Expertise field
Medecine and Health
+ Research topics
- Role of HPV in head neck cancers - Role of sentinel node biopsy in head neck cancers - Role of robotic surgery in head and neck cancers
+ Publications and communications
• Sédillot-Daniel E, Melkane A, Chiesa C, Fakhry N, Young VN, Smith LJ, Lechien JR, Guertin L, Olivier MJ, Maniakas A, Jun Lin R, Bissada E, Christopoulos A, Ayad T, Leclerc AA. Development of the “LAser Surgical skills Evaluation for Residents” (LASER) Scale through a modified Delphi method. J Otolaryngol Head Neck Surg. 2024 Jan-Dec53:19160216241278654. • Khoury P, Khazen R, Melkane AE. A massive multicystic parapharyngeal tumor: a case report. Heliyon. 2024 Jun 1010(12):e32820. • Makhoul M, Melkane AE, Khoury PE, Hadi CE, Matar N. A cross-sectional comparative study: ChatGPT 3.5 versus diverse levels of medical experts in the diagnosis of ENT diseases. Eur Arch Otorhinolaryngol. 2024 May281(5):2717-2721. • Chiesa-Estomba CM, Mayo-Yanez M, Mannelli G, Molteni G, Lechien JR, Fakhry N, Melkane A, Calvo-Henriquez C, Kalfert D, Ayad T. Marginal versus segmental mandibulectomy in the treatment of oral cavity cancer: A systematic review meta-analysis. Int Arch Otorhinolaryngol. 2023 Apr 11;27(4):e733-e743. • Benali J, Viljoen G, Ayad T, Gravier-Dumonceau R, Ceccon FP, Tangjaturonrasme N, Saibene AM, Chiesa-Estomba C, Melkane AE, Allen J, Lim CM, Mayo-Yañez M, Tucciarone M, Sargi Z, Mouawad F, Ramirez AT, Magaró M, Michel J, Radulesco T, Giovanni A, Fagan JJ, Hao SP, Lechien JR, Giorgi R, Fakhry N. Management of oral feeding following total laryngectomy around the world: A YO-IFOS international study. Head Neck. 2022 Aug;44(8):1755-1764. • Cherfane P, Smaily H, Khalaf MG, Ghaoui N, Melkane AE. Otolaryngologic manifestations of diffuse idiopathic skeletal hyperostosis (Forestier’s disease): A systematic review of the literature. Joint Bone Spine. 2021 Dec;88(6):105218. • Lechien JR, Chiesa-Estomba CM, Fakhry N, Saussez S, Badr I, Ayad T, Chekkoury-Idrissi Y, Melkane AE, Bahgat A, Crevier-Buchman L, Blumen M, Cammaroto G, Vicini C, Hans S. Surgical, clinical, functional outcomes of transoral robotic surgery used in sleep surgery for obstructive sleep apnea syndrome: A systematic review meta-analysis. Head Neck. 2021 Jul;43(7):2216-2239. • Khalaf MG, Nassereddine H, Chahine G, Melkane AE. An unusual metastatic submandibular gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 2021 Oct;138(5):411-412. • Smaily H, Khalaf M, Melkane A, Helou D, Richa T, Khoury C, Azoury F, Farha G, Haddad A, Matar N. Smoking cessation intervention for patients with head and neck cancer: a prospective randomized clinical trial. Am J Otolaryngol. 2021 Jan-Feb;42(1):102832. • Khalaf M, Haddad R, Akiki M, Khazen J, Melkane AE. Multifocal adult rhabdomyoma of the head and neck: Case report and systematic review of the literature. Int J Oral Maxillofac Surg. 2021 Mar;50(3):327-334. • Sowerby LJ, Stephenson K, Dickie A, Lella FAD, Jefferson N, North H, De Siati RD, Maunsell R, Herzog M, Nandhan R, Trozzi M, Dehgani-Mobaraki P, Melkane A, Callejas C, Miljeteig H, Smit D, Reynoso DD, Moura JE, Hermansson A, Peer S, Burnell L, Fakhry N, Chiesa-Estomba C, Önerci Çelebi Ö, Karpischenko S, Sobol S, Sargi Z, Patel ZM. International Registry of Otolaryngologist - Head and Neck Surgeons with COVID-19. Int Forum Allergy Rhinol. 2020 Nov;10(11):1201-1208. • Lechien JR, Fakhry N, Saussez S, Chiesa-Estomba CM, Chekkoury-Idrissi Y, Cammaroto G, Melkane AE, Barillari MR, Crevier-Buchman L, Ayad T, Remacle M, Hans S. Surgical, clinical and functional outcomes of transoral robotic surgery for supraglottic laryngeal cancers: A systematic review. Oral Oncol. 2020 Jun 10;109:104848. • Chiesa-Estomba CM, Lechien JR, Fakhry N, Melkane A, Calvo-Henriquez C, de Siati D, Gonzalez-Garcia JA, Fagan JJ, Ayad T. Systematic review of international guidelines for perioperative antibiotic prophylaxis in Head & Neck Surgery. A YO-IFOS Head & Neck Study Group Position Paper. Head Neck. 2019 Sep;41(9):3434-3456. • Richa T, Ghorra C, Melkane AE. Unusual presentation of Merkel Cell Carcinoma. Ear Nose Throat J. 2020 Mar;99(3):200-202. • Fournier I, Stephenson K, Fakhry N, Jia H, Sampathkumar R, Lechien JR, Melkane AE, Bahgat AY, De Carvalho Lopes K, Kennel T, Teissier N, Ayad T. Barriers to research among residents in Otolaryngology - Head & Neck Surgery around the world. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Jun;136(3S):S3-S7. • Mhawej R, Ghorra C, Naderi S, Khoueir N, Abou Hamad W, Melkane AE. Human papillomavirus prevalence and clinicopathological associations in oropharyngeal squamous cell carcinoma in the Lebanese population. J Laryngol Otol. 2018 Jul;132(7):636-641. • Moya-Plana A, Aupérin A, Guerlain J, Gorphe P, Casiraghi O, Mamelle G, Melkane A, Lumbroso J, Janot F, Temam S. Sentinel node biopsy in early oral squamous cell carcinomas: Long-term follow-up and nodal failure analysis. Oral Oncol. 2018 Jul; 82: 187-194. • Mirghani H, Casiraghi O, Guerlain J, Amen F, He MX, Ma XJ, Luo Y, Mourareau C, Drusch F, Lakdhar AB, Melkane A, St Guily L, Badoual C, Scoazec JY, Borget I, Aupérin A, Dalstein V, Vielh P. Diagnosis of HPV driven oropharyngeal cancers: Comparing p16 based algorithms with the RNAscope HPV-test. Oral Oncol. 2016 Nov; 62: 101-108. • Cohen DS, Low GM, Melkane AE, Mutchnick SA, Waxman JA, Patel S, Shkoukani MA, Lin HS. Establishing a danger zone: An anatomic study of the lingual artery in base of tongue surgery. Laryngoscope. 2017 Jan; 127(1): 110-115. • Mhawej R, Richa T, Melkane AE. Benign lymphoepithelial cyst of unusual location: a case report. Acta Oto-Laryngologica Case Reports. 2016 Nov; 1(1): 110-112. • Hurst NJ, Dominello M, Dyson G, Jaratli H, Sharma M, Ahmed Y, Melkane AE, Rose CT, Jacobs JR, Giorgadze T, Kim H. Intratumoral lymphatic vessel density as a predictor of progression-free and overall survival in locally advanced laryngeal/hypopharyngeal cancer. Head Neck. 2016 Apr; 38 Suppl 1: E417-20. • Lacroix L, Post S, Valent A, Melkane AE, Lefebvre AM, Egile C, Castell C, Saulnier P, Goulaouic H, Temam S. MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma. PLoS One. 2014 Jan 17;9(1):e84319. • Mirghani H, Amen F, Moreau F, Guigay J, Ferchiou M, Melkane AE, Hartl DM, Lacau St Guily J. Human papilloma virus testing in oropharyngeal squamous cell carcinoma: what the clinician should know. Oral Oncol. 2014 Jan; 50(1): 1-9. • Melkane AE, Mirghani H, Auperin A, Saulnier P, Lacroix L, Vielh P, Casiraghi O, Griscelli F, Temam S. HPV-related oropharyngeal squamous cell carcinomas: a comparison between three diagnostic approaches. Am J Otolaryngol. 2014 Jan-Feb; 35(1): 25-32. • Melkane AE, Auperin A, Saulnier P, Lacroix L, Vielh P, Casiraghi O, Msakni I, Drusch F, Temam S. Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas. Head Neck. 2014 Feb; 36(2): 257-65. • Melkane AE, Mamelle G, Wycisk G, Temam S, Janot F, Casiraghi O, Lumbroso J. Sentinel node biopsy in early oral squamous cell carcinomas: a ten-year experience. Laryngoscope. 2012 Aug; 122(8): 1782-8. • Aouad R, Matar N, Melkane A, Nassar M, Almoutran H, Haddad A. Sulfuric acid ingestion. J Trauma. 2011 May; 70(5): E98. • Melkane AE, Matar N, Haddad A, Zoghbi A. Suicidal hanging attempt: poor symptoms for a potentially lethal injury. J Trauma. 2010 Oct; 69(4): E36. • Aouad R, Melkane A, Rassi S. Lemierre’s syndrome: unusual cause and presentation. Pediatr Emerg Care. 2010 May; 26(5): 376-7. • Melkane AE, Matar NE, Haddad AC, Nassar MN, Almoutran HG, Rohayem Z, Daher M, Chalouhy G, Dabar G. Management of post-intubation tracheal stenosis: appropriate indications make outcome differences. Respiration. 2010; 79(5): 395-401. • Abboud B, Sleilaty G, Braidy C, Melkane A, Nasr F. Thyroidectomy in patients at high-risk of bleeding: can it be safely performed? Minerva Chir. 2009 Dec; 64(6): 565-71. • Rassi SJ, Melkane AE, Rizk HG, Dahoui HA. Sinonasal mucormycosis in immunocompromised pediatric patients. J Pediatr Hematol Oncol. 2009 Dec;31(12): 907-10. • Matar NE, Rassi SJ, Melkane AE, Haddad AC. Lateral sinus thrombosis in the pediatric population: multiple presentations for a potentially lethal disease. Pediatr Emerg Care. 2009 Oct; 25(10): 681-3. • Razfar A, Walvekar R, Melkane A, Johnson J, Myers E. Incidence and patterns of regional metastasis in early oral squamous cell cancers: feasibility of submandibular gland preservation. Head Neck. 2009 Dec; 31(12): 1619-23.